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ferroorange fluorescent probe  (Dojindo Labs)


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    Dojindo Labs ferroorange fluorescent probe
    Ferroorange Fluorescent Probe, supplied by Dojindo Labs, used in various techniques. Bioz Stars score: 99/100, based on 1877 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/fluorescent+probe+ferroorange/FerroOrange/pmc13080478-77-12-15
    Average 99 stars, based on 1877 article reviews
    ferroorange fluorescent probe - by Bioz Stars, 2026-09
    99/100 stars

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    Related Articles

    other:

    Article Title: Kaempferide alleviates glucocorticoid-induced osteoporosis by targeting ferroptosis through the GSK3β/Nrf-2/GPX4 pathway.
    Article Snippet: Glucocorticoid-induced osteoporosis (GIOP) is a common complication of long-term glucocorticoid use, with ferroptosis playing a key role in its pathogenesis.. This study investigates whether Kaempferide (KF), a flavonoid derived from traditional Chinese medicine, protects against dexamethasone (Dex)-induced osteoblast ferroptosis and bone loss.. In vitro, KF treatment enhanced antioxidant capacity, reduced lipid peroxidation and mitochondrial ROS, and promoted osteogenic differentiation in Dex-exposed osteoblasts.

    Article Title: Iron Metabolism as a Therapeutic Vulnerability in Stem Cell-Like Castration-Resistant Prostate Cancer
    Article Snippet: Intracellular chelatable iron was determined using the fluorescent probe FerroOrange from Dojindo (F374).

    Article Title: PHB2 ameliorates ferroptosis and aortic aneurysm/dissection through NEDD4L-dependent ubiquitination of NCOA4
    Article Snippet: Intracellular labile ferrous iron (Fe 2+ ) levels were detected using the fluorescent probe FerroOrange (F374, Dojindo Laboratories) according to the manufacturer's instructions.

    Article Title: A novel mechanism of chlorogenic acid against type 2 diabetes-induced diabetic retinopathy: suppressing ferroptosis via NRF2/xCT/GPX4 and STAT3 signaling.
    Article Snippet: Diabetic retinopathy (DR) is a common microvascular complication of type 2 diabetes (T2D), driven by hyperglycemiainduced oxidative stress, ferroptosis, and inflammatory signaling.. Here, we demonstrate that chlorogenic acid (CGA) ameliorates T2D and DR by simultaneously modulating the NRF2/xCT/GPX4 antioxidant pathway and the p-STAT3/xCT/ GPX4 inflammatory-ferroptosis axis.. High-fat diet (HFD) combined with streptozotocin (STZ)-induced T2D mice and high-glucose (HG)-stimulated human retinal microvascular endothelial cells (HRMECs) were used to evaluate the effects of CGA in vivo and in vitro.

    Article Title: PHB2 ameliorates ferroptosis and aortic aneurysm/dissection through NEDD4L-dependent ubiquitination of NCOA4.
    Article Snippet: Intracellular labile ferrous iron (Fe2+) levels were detected using the fluorescent probe FerroOrange (F374, Dojindo Laboratories) according to the manufacturer's instructions.

    Article Title: Targeting the USP5-HSPB1 axis overcomes ferroptosis resistance in intrahepatic cholangiocarcinoma.
    Article Snippet: Ferroptosis evasion contributes to therapeutic resistance in intrahepatic cholangiocarcinoma (ICC), yet the ubiquitin-dependent mechanisms governing this process remain poorly defined.. Here, we identify ubiquitinspecific protease 5 (USP5) as a clinically relevant ferroptosis suppressor in ICC.. USP5 was frequently upregulated in human ICC specimens, and elevated USP5 expression was associated with adverse clinicopathological features and poor outcomes.

    Peroxidation Assay:

    Article Title: Heme Synthesis Inhibition Induces the Intrinsic Apoptosis Pathway in Leukemia with OSGIN1 Upregulation.
    Article Snippet: Acute myeloid leukemia (AML) is one of the hematological malignancies with a poor outcome.. AML has a unique metabolic status, and identifying its metabolic vulnerabilities is warranted.. Recent genome-wide screenings suggest that heme synthesis might be such a vulnerability.

    Staining:

    Article Title: Chemically Engineered L. reuteri Delivering αPD-L1 and Gallium Ions via Metal-Phenolic Networks Potentiate Anti-Tumor Immunity and Ferroptosis.
    Article Snippet: .. Tumor cells were stained with the Fe2 + -specific fluorescent probe FerroOrange (Dojindo) to visualize the intracellular Fe2 + pool. ..



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    Ketone ester and β-OHB mitigate lipid peroxidation and iron accumulation. ( A ) Representative fluorescence images of C11-BODIPY staining in HASMCs from various treatment groups: Control, β-OHB, RSL3, and RSL3 + β-OHB treatment groups, showing both reduced (red) and oxidized (green) lipid signals. Scale bar = 100 µm. ( B ) Quantitative analysis of the C11-BODIPY fluorescence ratio (Oxidized/Total), indicating the degree of lipid peroxidation. ( C ) Representative fluorescence images of <t>FerroOrange</t> staining in HASMCs used to detect intracellular labile iron (Fe 2+ ) in Control, β-OHB, Fer-1, RSL3, RSL3 + β-OHB, and RSL3 + Fer-1 groups. Scale bar = 100 µm. ( D ) Quantification of FerroOrange Mean Fluorescence Intensity. ( E ) Relative concentration of malondialdehyde (MDA) measured via TBARS assay across the indicated experimental groups in HASMCs. ( F ) Representative images of Prussian blue staining in aortic tissue sections from Control, BAPN, and BAPN + KE mice cohortsblue arrows indicating in vivo iron deposition. Scale bars = 100 µm and 20 µm. ( G ) Quantification of Prussian blue spot density (spots/mm 2 ). Data are presented as mean ± SEM ( n = 3–6 per group). * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. β-OHB: 5 mM; Fer-1 (Ferrostatin-1): 2 µM; RSL3: 200 nM (2 h).
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    Ketone ester and β-OHB mitigate lipid peroxidation and iron accumulation. ( A ) Representative fluorescence images of C11-BODIPY staining in HASMCs from various treatment groups: Control, β-OHB, RSL3, and RSL3 + β-OHB treatment groups, showing both reduced (red) and oxidized (green) lipid signals. Scale bar = 100 µm. ( B ) Quantitative analysis of the C11-BODIPY fluorescence ratio (Oxidized/Total), indicating the degree of lipid peroxidation. ( C ) Representative fluorescence images of <t>FerroOrange</t> staining in HASMCs used to detect intracellular labile iron (Fe 2+ ) in Control, β-OHB, Fer-1, RSL3, RSL3 + β-OHB, and RSL3 + Fer-1 groups. Scale bar = 100 µm. ( D ) Quantification of FerroOrange Mean Fluorescence Intensity. ( E ) Relative concentration of malondialdehyde (MDA) measured via TBARS assay across the indicated experimental groups in HASMCs. ( F ) Representative images of Prussian blue staining in aortic tissue sections from Control, BAPN, and BAPN + KE mice cohortsblue arrows indicating in vivo iron deposition. Scale bars = 100 µm and 20 µm. ( G ) Quantification of Prussian blue spot density (spots/mm 2 ). Data are presented as mean ± SEM ( n = 3–6 per group). * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. β-OHB: 5 mM; Fer-1 (Ferrostatin-1): 2 µM; RSL3: 200 nM (2 h).
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    Image Search Results


    Ketone ester and β-OHB mitigate lipid peroxidation and iron accumulation. ( A ) Representative fluorescence images of C11-BODIPY staining in HASMCs from various treatment groups: Control, β-OHB, RSL3, and RSL3 + β-OHB treatment groups, showing both reduced (red) and oxidized (green) lipid signals. Scale bar = 100 µm. ( B ) Quantitative analysis of the C11-BODIPY fluorescence ratio (Oxidized/Total), indicating the degree of lipid peroxidation. ( C ) Representative fluorescence images of FerroOrange staining in HASMCs used to detect intracellular labile iron (Fe 2+ ) in Control, β-OHB, Fer-1, RSL3, RSL3 + β-OHB, and RSL3 + Fer-1 groups. Scale bar = 100 µm. ( D ) Quantification of FerroOrange Mean Fluorescence Intensity. ( E ) Relative concentration of malondialdehyde (MDA) measured via TBARS assay across the indicated experimental groups in HASMCs. ( F ) Representative images of Prussian blue staining in aortic tissue sections from Control, BAPN, and BAPN + KE mice cohortsblue arrows indicating in vivo iron deposition. Scale bars = 100 µm and 20 µm. ( G ) Quantification of Prussian blue spot density (spots/mm 2 ). Data are presented as mean ± SEM ( n = 3–6 per group). * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. β-OHB: 5 mM; Fer-1 (Ferrostatin-1): 2 µM; RSL3: 200 nM (2 h).

    Journal: Cells

    Article Title: Ketone Ester Attenuates Thoracic Aortic Aneurysm and Dissection by Suppressing Ferroptosis

    doi: 10.3390/cells15090829

    Figure Lengend Snippet: Ketone ester and β-OHB mitigate lipid peroxidation and iron accumulation. ( A ) Representative fluorescence images of C11-BODIPY staining in HASMCs from various treatment groups: Control, β-OHB, RSL3, and RSL3 + β-OHB treatment groups, showing both reduced (red) and oxidized (green) lipid signals. Scale bar = 100 µm. ( B ) Quantitative analysis of the C11-BODIPY fluorescence ratio (Oxidized/Total), indicating the degree of lipid peroxidation. ( C ) Representative fluorescence images of FerroOrange staining in HASMCs used to detect intracellular labile iron (Fe 2+ ) in Control, β-OHB, Fer-1, RSL3, RSL3 + β-OHB, and RSL3 + Fer-1 groups. Scale bar = 100 µm. ( D ) Quantification of FerroOrange Mean Fluorescence Intensity. ( E ) Relative concentration of malondialdehyde (MDA) measured via TBARS assay across the indicated experimental groups in HASMCs. ( F ) Representative images of Prussian blue staining in aortic tissue sections from Control, BAPN, and BAPN + KE mice cohortsblue arrows indicating in vivo iron deposition. Scale bars = 100 µm and 20 µm. ( G ) Quantification of Prussian blue spot density (spots/mm 2 ). Data are presented as mean ± SEM ( n = 3–6 per group). * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. β-OHB: 5 mM; Fer-1 (Ferrostatin-1): 2 µM; RSL3: 200 nM (2 h).

    Article Snippet: Intracellular labile ferrous iron (Fe 2+ ) was detected using the live-cell fluorescent probe FerroOrange (Dojindo, Rockville, MD, USA, Cat. No. F374).

    Techniques: Fluorescence, Staining, Control, Concentration Assay, TBARS Assay, In Vivo